The Science Behind Dentyl Mouthwash

Unique Formula

The unique Dentyl Dual Action formula was developed in the 1980s by one of the world’s leading dental experts and is backed by several scientific studies. Just over thirty years ago, Professor Mel Rosenberg of Tel Aviv University, was inspired to create a revolutionary new plaque fighting, breath-freshening mouthwash with an innovative formula.

The technology is based on a two-phase formulation that consists of an oil phase and a water phase, which combine when shaken.

Its key ingredient is Cetylpyridinium Chloride (CPC), which disrupts the membrane – the fatty outer layer – of the bacteria. This allows the unique Dentyl formulation to remove the bacteria from the mouth, both quickly and effectively.

Research shows that an oil-in-water solution enhances the performance of the antimicrobial agent, by prolonging its release over a period of time.

When shaken the two liquids combine to activate. Unlike other mouthwashes, this unique formulation physically lifts and removes plaque and bacteria from the mouth, that you can see instantly when you rinse.

Dentyl Dual Action is the only mouthwash on the market to contain both CPC and IPM, and provides longer lasting protection for the mouth.

An oil-based solution of essential oils and aromas.

A water-based solution containing an antimicrobial agent called Cetylpyridinium Chloride (CPC), which eliminates 99% of bacteria (and unlike alcohol, it won’t sting or burn) and Sodium Fluoride, which can help strengthen the tooth enamel, making it more resistant to tooth decay.

Dentyl Dual Action uses the negative charge of oral micro-organisms (bacteria), which sit within the biofilm/plaque on both the teeth and gums, and it uses this charge to remove the plaque/bacteria from the mouth.


The cationic (positively charged) CPC, uses the bacteria’s anionic (negatively charged) properties to efficiently bind1 with them. Once bound, the charge of the bacteria is reduced, increasing their hydrophobicity (dislike of water), which in turn increases their preference for the oil droplets2 within the emulsion – much like metal shavings are attracted to a magnet, for example.

Plaque Removal

This enhanced affinity for the oil phase allows Dentyl Dual Action to act as a carrier, physically lifting and removing3 these microbes (and therefore the plaque) from the mouth.

Visible Results

The accumulated plaque, bacteria and food debris presents as colourful specks in the mouthwash when it is expelled into the sink.

Developed by experts,
clinically proven.

Supplementing your usual routine with a 30-second swish of Dentyl Dual Action both morning and night will give you whole mouth protection to prevent the build-up of plaque – with instant results you can see in the sink. Dentyl Dual Action removes 99.9% of bacteria1

1 Clinically tested under dental control on 20 subjects/volunteers, for 28 days of use, twice a day (Date on file, 2019 study)

Day-long reduction of oral malodour by a two-phase oil:water mouth rinse as compared to chlorhexidine and placebo rinses4:

Results showed that:

  • The two-phase mouthwash significantly reduced oral sulphides, as compared with the placebo rinse
  • The positive control used within the study (Chlorhexidine mouthwash) appeared to be somewhat more effective than the two-phase mouthwash in reducing sulphide levels, although importantly, the two groups were not significantly different
  • The two-phase mouthwash and the positive control brought about highly significant, dramatic decreases in the level of oral microorganisms

Effect of CPC on microbial adhesion to hexadecane and polystyrene1:

The clinical study demonstrated that the cationic surfactant cetylpyridinium chloride (CPC) significantly enhanced microbial adhesion to hexadecane and various other oils.

The results also concluded that:

  • CPC acts to enhance adhesion by binding directly to the cell surface
  • The surfactant acts by binding via its positive charge to negatively charged groups at the cell surface. The exposed hydrophobic moiety of the bound CPC molecules can then increase cell surface hydrophobicity, enabling partitioning of the cells at the oil-water interface
  • The reduction in the net negative surface charge of the cell may also contribute to the hydrophobic properties observed
  • Binding of CPC to the cell surface may promote cell-cell bridging, which may stabilize adhesion. Optimal CPC concentrations for enhanced adhesion brought about some aggregation when added prior to mixing with hexadecane

Plaque Reduction, Fresh Breath, and Gingival Health

Our most recent study5 has further concluded that the dual phase technology of Dentyl Dual Action:

  • Reduces plaque by 35% within 12 hours of first use, and by over 60% after 28 days
  • Improves gingival health by 36% with 12 hours of first use, and by 63% after 28 days
  • Removes oral bacterial
  • Freshens breath for up to 12 hours
  • Clinically tested under dental control on 28 subjects/volunteers for 28 days of use, twice per day.
  1. Goldberg, S., Konis, Y, and Rosenberg, M. 1990. Effect of cetylpyridinium chloride on microbial adhesion to hexadecane and polystyrene. Applied and environmental microbiology, 56, 6:1768-1682.
  2. Rosenberg, M., E, Rosenberg, H. Judes and E. Weiss. 1983. Bacterial adherence to hydrocarbons and to surfaces in the oral cavity. FEMS Microbiol. Lett 20:1-5.
  3. Goldberg, S. and Rosenberg, M. Bacterial desorption by commercial mouthwashes vs two-phase oil:water formulations. Biofouling 1991; 3: 193-198.
  4. Rosenberg, M., Gelernter, I., Barki, M. and Bar-Ness, R. 1992. Day-Long Redcution of oral Malodor by a Two-Phase Oil:Water Mouthrinse and Compared to Chlorhexidine and Placebo Rinses. J. Periodontol 1992; 63: 39-42
  5. Assessment of the anti-plaque efficacy, evaluation of the gingival state of health and measurement of VSCs Eurofins Biopharma Product Testing Kalibios S.r.l., Italy 2019. Data on file.

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